Zomig-ZMT

Generic Name: zolmitriptan (Oral route)

zole-mi-TRIP-tan

Commonly used brand name(s)

In the U.S.

• Zomig


• Zomig-ZMT

Available Dosage Forms:

• Tablet


• Tablet, Disintegrating

Therapeutic Class: Antimigraine

Pharmacologic Class: Serotonin Receptor Agonist, 5-HT1

Uses For Zomig-ZMT

Zolmitriptan is used to treat severe migraine headaches. Many people find that their headaches go away completely after they take zolmitriptan. Other people find that their headaches are much less painful, and that they are able to go back to their normal activities even though their headaches are not completely gone. Zolmitriptan often relieves symptoms that occur together with a migraine headache, such as nausea, vomiting, sensitivity to light, and sensitivity to sound.

Zolmitriptan is not an ordinary pain reliever. It should not be used to relieve any kind of pain other than migraine headaches.

Zolmitriptan may cause serious side effects in some people, especially people who have heart or blood vessel disease. Be sure that you discuss with your doctor the risks of using this medicine as well as the good that it can do.

Zolmitriptan is available only with your doctor's prescription.

Before Using Zomig-ZMT

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There is no specific information comparing use of zolmitriptan in children or teenagers with use in other age groups.

Geriatric

There is no specific information comparing use of zolmitriptan in patients older than 65 years of age with use in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Almotriptan


• Cisapride


• Dihydroergotamine


• Eletriptan


• Ergoloid Mesylates


• Ergonovine


• Ergotamine


• Frovatriptan


• Isocarboxazid


• Levomethadyl


• Linezolid


• Mesoridazine


• Methylergonovine


• Methysergide


• Naratriptan


• Phenelzine


• Pimozide


• Procarbazine


• Rizatriptan


• Sumatriptan


• Terfenadine


• Thioridazine


• Tranylcypromine


• Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acecainide


• Ajmaline


• Amiodarone


• Amisulpride


• Amitriptyline


• Amoxapine


• Aprindine


• Azimilide


• Bretylium


• Chloroquine


• Citalopram


• Clarithromycin


• Clovoxamine


• Desipramine


• Desvenlafaxine


• Dibenzepin


• Disopyramide


• Dofetilide


• Dolasetron


• Doxepin


• Droperidol


• Duloxetine


• Erythromycin


• Escitalopram


• Femoxetine


• Flecainide


• Fluconazole


• Fluoxetine


• Fluvoxamine


• Foscarnet


• Gemifloxacin


• Halofantrine


• Haloperidol


• Hydroquinidine


• Ibutilide


• Imipramine


• Isradipine


• Lidoflazine


• Lorcainide


• Mefloquine


• Milnacipran


• Nefazodone


• Nortriptyline


• Octreotide


• Paroxetine


• Pentamidine


• Pirmenol


• Prajmaline


• Probucol


• Procainamide


• Prochlorperazine


• Propafenone


• Protriptyline


• Quetiapine


• Quinidine


• Reboxetine


• Risperidone


• Sematilide


• Sertindole


• Sertraline


• Sibutramine


• Sotalol


• Spiramycin


• St John's Wort


• Sultopride


• Tapentadol


• Tedisamil


• Trifluoperazine


• Trimipramine


• Vasopressin


• Venlafaxine


• Vilazodone


• Zimeldine


• Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Cimetidine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina (chest pain) or


• Fast or irregular heartbeat or


• Heart or blood vessel disease or


• High blood pressure or


• Kidney disease or


• Liver disease or


• Stroke (history of)—The chance of side effects may be increased. Heart or blood vessel disease and high blood pressure sometimes do not cause any symptoms, so some people do not know that they have these problems. Before deciding whether you should use zolmitriptan, your doctor may need to do some tests to make sure that you do not have any of these conditions.

• Phenylketonuria (PKU)—The oral disintegrating tablets may contain aspartame, which can make your condition worse

Proper Use of zolmitriptan

This section provides information on the proper use of a number of products that contain zolmitriptan. It may not be specific to Zomig-ZMT. Please read with care.

Do not use zolmitriptan for a headache that is different from your usual migraines . Instead, check with your doctor.

To relieve your migraine as soon as possible, use zolmitriptan as soon as the headache pain begins. Even if you get warning signals of a coming migraine (an aura), you should wait until the headache pain starts before using zolmitriptan.

Lying down in a quiet, dark room for a while after you use this medicine may help relieve your migraine.

Ask your doctor ahead of time about other medicine you might take if zolmitriptan does not work. After you take the other medicine, check with your doctor as soon as possible. Headaches that are not relieved by zolmitriptan are sometimes caused by conditions that need other treatment.

If you feel much better after a dose of zolmitriptan, but your headache comes back or gets worse after a while, you may use more zolmitriptan. However, use this medicine only as directed by your doctor. Do not use more of it, and do not use it more often, than directed. Using too much zolmitriptan may increase the chance of side effects.

Your doctor may direct you to take another medicine to help prevent headaches. It is important that you follow your doctor's directions, even if your headaches continue to occur. Headache-preventing medicines may take several weeks to start working. Even after they do start working, your headaches may not go away completely. However, your headaches should occur less often, and they should be less severe and easier to relieve. This can reduce the amount of zolmitriptan or other pain medicines that you need. If you do not notice any improvement after several weeks of headache-preventing treatment, check with your doctor.

For patients using the oral disintegrating tablet form of this medicine:

• Make sure your hands are dry.


• Remove tablet from package, and immediately place the tablet on top of your tongue.


• The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For migraine headaches:
    
    • Adults—2.5 mg or lower (tablet may be broken in half) as a single dose. If the migraine comes back after being relieved, another dose may be taken two hours after the last dose. Do not take more than 10 mg in any twenty-four-hour period (one day).
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  


• For oral dosage form (oral disintegrating tablets):
  
  • For migraine headaches:
    
    • Adults—2.5 mg placed on top of your tongue. If the migraine comes back after being relieved, another dose may be taken two hours after the last dose. Do not take more than 10 mg in any twenty-four-hour period (one day).
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Zomig-ZMT

Drinking alcoholic beverages can make headaches worse or cause new headaches to occur. People who suffer from severe headaches should probably avoid alcoholic beverages, especially during a headache.

Some people feel drowsy or dizzy during or after a migraine, or after taking zolmitriptan to relieve a migraine. As long as you are feeling drowsy or dizzy, do not drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.

Zomig-ZMT Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

More common

• Chest pain (severe)


• heaviness, tightness, or pressure in chest and/or neck


• sensation of burning, warmth, heat, numbness, tightness, or tingling

Less common or rare

• Abdominal pain (severe)


• changes in facial skin color


• cough or hoarseness


• diarrhea


• fast or irregular heartbeat


• fever or chills


• loss of appetite


• lower back or side pain


• nausea


• painful or difficult urination


• puffiness or swelling of the eyelids or around the eyes, face, or lips


• shortness of breath, troubled breathing, tightness in chest, and/or wheezing


• skin rash, hives, and/or itching


• weakness

Other side effects may occur that usually do not need medical attention. Some of the following effects, such as nausea, vomiting, drowsiness, dizziness, and general feeling of illness or tiredness, often occur during or after a migraine, even when zolmitriptan has not been used. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

• Dizziness


• nausea


• sleepiness


• unusual tiredness or muscle weakness

Less common

• Agitation


• anxiety


• depression


• discomfort in jaw, mouth, or throat


• difficulty in swallowing


• dry mouth


• fainting


• heartburn


• itching of the skin


• large nonelevated blue or purplish patches in the skin


• muscle aches


• pounding heartbeat


• sudden large increase in frequency and quantity of urine


• sweating


• swelling of face, fingers, feet and/or lower legs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Zomig-ZMT side effects (in more detail)

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More Zomig-ZMT resources

• Zomig-ZMT Side Effects (in more detail)
• Zomig-ZMT Use in Pregnancy & Breastfeeding
• Drug Images
• Zomig-ZMT Drug Interactions
• Zomig-ZMT Support Group
• 7 Reviews for Zomig-ZMT - Add your own review/rating

• Zolmitriptan Professional Patient Advice (Wolters Kluwer)


• Zolmitriptan Monograph (AHFS DI)


• Zolmitriptan MedFacts Consumer Leaflet (Wolters Kluwer)


• Zomig Prescribing Information (FDA)


• Zomig Consumer Overview

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